曹萤实验室
PI简介：
曹萤，自1998至2002年间在德国埃森大学（现杜伊斯堡－埃森大学）攻读博士学位。其间从事非洲爪蛙的发育生物学研究。于2002年获得博士学位，并以优异成绩毕业（Graduated summa cum laude）。在2002至2008年间，在德国乌尔姆大学继续从事非洲爪蛙早期胚胎细胞分化的机理研究工作。自2008年起，加入南京大学模式动物研究所，从事早期胚胎细胞的分化研究。同时，依据发育生物学原理，发现了肿瘤发生／发展无穷复杂性表象下所遵循的普遍规律，提出了原创的基础理论框架：1）神经干性（neural stemness）是基础干性，决定着细胞致瘤性和分化潜能，这是因为神经基因和神经干细胞状态具有进化上的优势；2)肿瘤发生发展的过程是细胞失去原有特性并获得神经干细胞特性（也就是神经干性）的过程；3）细胞的多能性和致瘤性是同一种细胞特性，也就是神经干性，分别在动物生命的不同阶段——胚胎期和出生后——的不同体现；4）致瘤性本质上是在出生后的动物细胞中异常产生的多能性状态的体现；5）胚胎发育过程中的神经诱导(neural induction)决定胚胎体轴发育，而在出生后动物（包括人）中，一个类似的过程决定肿瘤形成。这些发现不仅揭示了癌细胞的本质是神经干性，也把两种关键细胞特性，致瘤性和多能性分化潜能统一起来，也就是把胚胎发育和肿瘤形成统一起来，能够揭示肿瘤发生发展的不同现象，并且具有转化应用的潜力。此外，揭示了上皮-间质转化（EMT）、间质-上皮转化（MET）、内皮-间质转化（EndMT）等细胞状态转化的概念不具备基本的逻辑合理性，因此不具备成为科学概念的基础。
联系方式：
办公室：025-58641537
实验室：025-58641539
研究所邮箱：caoying@nicemice.cn
南大邮箱：caoying@nju.edu.cn
实验室：025-58641539
研究所邮箱：caoying@nicemice.cn
南大邮箱：caoying@nju.edu.cn
研究方向：1) 神经干性作为细胞的基础干性对细胞致瘤性和多能性分化潜能的决定作用；2）神经干性作为癌（致瘤性）细胞的本质特性在肿瘤治疗中的应用。
代表性论文（#第一作者； *通讯作者）
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1 Cao Y. Lack of basic rationale in epithelial-mesenchymal transition and its related concepts. Cell Biosci. 2024 Aug 20;14(1):104.
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2 Cao Y. Neural induction drives body axis formation during embryogenesis, but a neural induction-like process drives tumorigenesis in postnatal animals. Front Cell Dev Biol. 2023;11:1092667.
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3 Zhang M, Liu Y, Shi L, Fang L, Xu L, Cao Y. Neural stemness unifies cell tumorigenicity and pluripotent differentiation potential. J Biol Chem. 2022 Jul;298(7):102106.
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4 - Cao Y. Neural is Fundamental: Neural Stemness as the Ground State of Cell Tumorigenicity and Differentiation Potential. Stem Cell Rev Rep. 2022 Jan;18(1):37-55.
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5 - Chen L, Zhang M, Fang L, Yang X, Cao N, Xu L, Shi L, Cao Y. Coordinated regulation of the ribosome and proteasome by PRMT1 in the maintenance of neural stemness in cancer cells and neural stem cells. J Biol Chem. 2021 Nov;297(5):101275.
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6 - Yang X, Cao N, Chen L, Liu L, Zhang M, Cao Y. Suppression of Cell Tumorigenicity by Non-neural Pro-differentiation Factors via Inhibition of Neural Property in Tumorigenic Cells. Front Cell Dev Biol. 2021 Sep 14;9:714383.
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7 - Xu L, Zhang M, Shi L, Yang X, Chen L, Cao N, Lei A, Cao Y. Neural stemness contributes to cell tumorigenicity. Cell Biosci. 2021 Jan 19;11(1):21.
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8 - Lei A, Chen L, Zhang M, Yang X, Xu L, Cao N, Zhang Z and Cao Y (2019). EZH2 Regulates Protein Stability via Recruiting USP7 to Mediate Neuronal Gene Expression in Cancer Cells. Front. Genet. 10:422.
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9 - Cao Y. (2017) Tumorigenesis as a process of gradual loss of original cell identity and gain of properties of neural precursor/progenitor cells. Cell Biosci (2017) 7:61.
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10 - Zhang Z, Lei AH, Xu LY, Chen L, Chen YL, Zhang XN, Gao Y, Yang XL, Zhang M, Cao Y (2017) Similarity in gene-regulatory networks suggests that cancer cells share characteristics of embryonic neural cells. J Biol Chem 292: 12842-12859
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11 - Gao Y, Cao Q, Lu L, Zhang X, Zhang Z, Dong X, Jia W, Cao Y*. Kruppel-like factor family genes are expressed during Xenopus embryogenesis and involved in germ layer formation and body axis patterning. Dev Dyn. 2015 Oct;244(10):1328-46. (*Correspondence).
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12 - Wang C, Kam RK, Shi W, Xia Y, Chen X, Cao Y, Sun J, Du Y, Lu G, Chen Z, Chan WY, Chan SO, Deng Y, Zhao H. The Proto-oncogene Transcription Factor Ets1 Regulates Neural Crest Development through Histone Deacetylase 1 to Mediate Output of Bone Morphogenetic Protein Signaling. J Biol Chem. 2015 Sep 4;290(36):21925-38.
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13 - Zhang X, Gao Y, Lu L, Zhang Z, Gan S, Xu L, Lei A, Cao Y*. JmjC Domain-containing Protein 6 (Jmjd6) Derepresses the Transcriptional Repressor Transcription Factor 7-like 1 (Tcf7l1) and Is Required for Body Axis Patterning during Xenopus Embryogenesis. J Biol Chem. 2015 Aug 14;290(33):20273-83. (*Correspondence).
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14 - Lu L, Gao Y, Zhang Z, Cao Q, Zhang X, Zou J, Cao Y*. Kdm2a/b Lysine Demethylases Regulate Canonical Wnt Signaling by Modulating the Stability of Nuclear β-Catenin. Dev Cell. 2015 Jun 22;33(6):660-74. (*Correspondence).
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15 - Cao Y*. Germ layer formation during Xenopus embryogenesis: the balance between pluripotency and differentiation (Review). Sci China Life Sci. 2015 Apr;58(4):336-42. (*Correspondence).
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16 - Cao Y*. Regulation of germ layer formation by pluripotency factors during embryogenesis (Review). Cell Biosci. 2013 Mar 11;3(1):15. (*Correspondence).
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17 - Cao Q, Zhang X, Lu L, Yang L, Gao J, Gao Y, Ma H, Cao Y*. Klf4 is required for germ-layer differentiation and body axis patterning during Xenopus embryogenesis. Development. 2012 Nov; 139(21):3950-61. (*Correspondence).
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18 - Cao Y, Oswald F, Wacker SA, Bundschu K, Knöchel W. Reversal of Xenopus Oct25 function by disruption of the POU domain structure. J Biol Chem. 2010 Mar 12;285(11):8408-21.
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19 - Siegel D, Schuff M, Oswald F, Cao Y, Knöchel W. Functional dissection of XDppa2/4 structural domains in Xenopus development. Mech Dev. 2009 Dec;126(11-12):974-89.
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20 - Cao Y, Siegel D, Oswald F, Knöchel W. Oct25 represses transcription of nodal/activin target genes by interaction with signal transducers during Xenopus gastrulation. J Biol Chem. 2008 Dec 5;283(49):34168-77.
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21 - Yuan L, Cao Y, Oswald F, Knöchel W. IRE1beta is required for mesoderm formation in Xenopus embryos. Mech Dev. 2008 Mar-Apr;125(3-4):207-22.
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22 - Yuan L, Cao Y, Knöchel W. Endoplasmic reticulum stress induced by tunicamycin disables germ layer formation in Xenopus laevis embryos. Dev Dyn. 2007 Oct;236(10):2844-51.
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23 - Cao Y, Siegel D, Donow C, Knöchel S, Yuan L, Knöchel W. POU-V factors antagonize maternal VegT activity and beta-Catenin signaling in Xenopus embryos. EMBO J. 2007 Jun 20;26(12):2942-54.
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24 - Cao Y, Siegel D, Knöchel W. Xenopus POU factors of subclass V inhibit activin/nodal signaling during gastrulation. Mech Dev. 2006 Aug;123(8):614-25.
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25 - Oswald F, Winkler M, Cao Y, Astrahantseff K, Bourteele S, Knöchel W, Borggrefe T. RBP-Jkappa/SHARP recruits CtIP/CtBP corepressors to silence Notch target genes. Mol Cell Biol. 2005 Dec;25(23):10379-90.
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26 - Cao Y, Knöchel S, Oswald F, Donow C, Zhao H, Knöchel W. XBP1 forms a regulatory loop with BMP-4 and suppresses mesodermal and neural differentiation in Xenopus embryos. Mech Dev. 2006 Jan;123(1):84-96.
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27 - Cao Y, Knöchel S, Donow C, Miethe J, Kaufmann E, Knöchel W. The POU factor Oct-25 regulates the Xvent-2B gene and counteracts terminal differentiation in Xenopus embryos. J Biol Chem. 2004 Oct 15;279(42):43735-43.
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28 - Zhao H, Cao Y, Grunz H. Xenopus X-box binding protein 1, a leucine zipper transcription factor, is involved in the BMP signaling pathway. Dev Biol. 2003 May 15;257(2):278-91.
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29 - Cao Y, Zhao H, Grunz H. XETOR regulates the size of the proneural domain during primary neurogenesis in Xenopus laevis. Mech Dev. 2002 Nov;119(1):35-44.
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30 - Zhao H, Cao Y, Grunz H. Isolation and characterization of a Xenopus gene (XMLP) encoding a MARCKS-like protein. Int J Dev Biol. 2001 Oct;45(7):817-26.
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31 - Cao Y, Zhao H, Grunz H. XCL-2 is a novel m-type calpain and disrupts morphogenetic movements during embryogenesis in Xenopus laevis. Dev Growth Differ. 2001 Oct;43(5):563-71.
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32 - Zhao H, Cao Y, Grunz H. Expression of Xenopus L-arginine:glycine amidinotransferase (XAT) during early embryonic development. Dev Genes Evol. 2001 Jul;211(7):358-60.
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33 - Cao Y, Zhao H, Hollemann T, Chen Y, Grunz H. Tissue-specific expression of an Ornithine decarboxylase paralogue, XODC2, in Xenopus laevis. Mech Dev. 2001 Apr;102(1-2):243-
| 基金种类 | 基金项目名称 |
|---|---|
| 国家自然科学基金 31271544 | 组蛋白去甲基化酶在非洲爪蛙胚层分化形成中的功能研究 |
| 国家自然科学基金 31261160492 | XBP1调节脊索形成的分子机制研究 |
硕士研究生
科研助理
技术员
硕士毕业生
博士毕业生 （2017年以后）
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李静 lijing@nicemice.cn
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王陈 wangchen@nicemice.cn
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刘洋 liuyang@nicemice.cn
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马海花 mahh@nicemice.cn
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石利华 shilh@nicemice.cn
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曹宁 caoning@nicemice.cn
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杨丽楠
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张赞 zhangzan@nicemice.cn
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雷安华 leiah@nicemice.cn
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徐李阳 xuly@nicemice.cn
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陈露 chenlu@nicemice.cn
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杨小丽 yangxl@nicemice.cn
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张敏 zhangmin@nicemice.cn
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曹青
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卢磊
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张雪娜
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高燕
