迟亮
实验室：025-58469102
邮箱：chiliang@nicemice.cn
目前实验室主要研究方向为：
• 性激素对皮肤免疫系统、脂质屏障和共生菌群的影响
• 激素微环境介导形成组织特异的免疫和代谢特征
• 激素干扰物以及食品成分对激素平衡以及对免疫系统和共生菌群的影响
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1 Chi, Liang, Can Liu, Inta Gribonika, Julia Gschwend, Dan Corral, Seong-Ji Han, Ai Ing Lim et al. "Sexual dimorphism in skin immunity is mediated by an androgen-ILC2-dendritic cell axis." Science 384, no. 6692 (2024): eadk6200.
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2 Chi, Liang, Xiaoming Bian, Bei Gao, Pengcheng Tu, Hongyu Ru, and Kun Lu. "Chronic sucralose consumption inhibits farnesoid X receptor signaling and perturbs lipid and cholesterol homeostasis in the mouse livers, potentially by altering gut microbiota functions." Science of The Total Environment 919 (2024): 169603.
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3 Chi, L., Tu, P., Ru, H., & Lu, K. Studies of xenobiotic-induced gut microbiota dysbiosis: from correlation to mechanisms. Gut Microbes. Gut Microbes, 13(1), 1921912.
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4 Chi, L., Lai, Y., Tu, P., Liu, C.W., Xue, J., Ru, H. and Lu, K., 2019. Lipid and Cholesterol Homeostasis after Arsenic Exposure and Antibiotic Treatment in Mice: Potential Role of the Microbiota. Environmental health perspectives, 127(9), p.097002.
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5 Chi, L., Tu, P., Liu, C.W., Lai, Y., Xue, J., Ru, H. and Lu, K., 2019. Chronic arsenic exposure Induces oxidative stress and perturbs serum lysolipids and fecal unsaturated fatty acid metabolism. Chemical research in toxicology, 32(6), pp.1204-1211.
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6 Chi, L., Xue, J., Tu, P., Lai, Y., Ru, H. and Lu, K., 2019. Gut microbiome disruption altered the biotransformation and liver toxicity of arsenic in mice. Archives of toxicology, 93(1), pp.25-35.
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7 Chi, L., Gao, B., Tu, P., Liu, C.W., Xue, J., Lai, Y., Ru, H. and Lu, K., 2018. Individual susceptibility to arsenic-induced diseases: the role of host genetics, nutritional status, and the gut microbiome. Mammalian genome, 29(1-2), pp.63-79.
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8 Chi, L., Bian, X., Gao, B., Tu, P., Lai, Y., Ru, H. and Lu, K., 2018. Effects of the artificial sweetener neotame on the gut microbiome and fecal metabolites in mice. Molecules, 23(2), p.367.
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9 Chi, L., Mahbub, R., Gao, B., Bian, X., Tu, P., Ru, H. and Lu, K., 2017. Nicotine Alters the Gut Microbiome and Metabolites of Gut–Brain Interactions in a Sex-Specific Manner. Chemical research in toxicology, 30(12), pp.2110-2119. (Selected as the cover article)
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10 Chi, L., Bian, X., Gao, B., Tu, P., Ru, H. and Lu, K., 2017. The effects of an environmentally relevant level of arsenic on the gut microbiome and its functional metagenome. Toxicological Sciences, 160(2), pp.193-204.
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11 Chi, L., Gao, B., Bian, X., Tu, P., Ru, H. and Lu, K., 2017. Manganese-induced sex-specific gut microbiome perturbations in C57BL/6 mice. Toxicology and applied pharmacology, 331, pp.142-153.
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12 Chi, L., Bian, X., Gao, B., Ru, H., Tu, P. and Lu, K., 2016. Sex-specific effects of arsenic exposure on the trajectory and function of the gut microbiome. Chemical research in toxicology, 29(6), pp.949-951.
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13 Chi, L., Lu, K., 2018. Chapter: Biotransformation by the Gut Microbiome. Comprehensive Toxicology (Third Edition).
