刘永振
实验室：025-58648902
邮箱：liuyz@nicemice.cn
乙型肝炎病毒（HBV）是引发肝硬化和肝癌等疾病的世界性流行病原体，全球2.96亿慢性感染者，对人类生命健康造成重大威胁。中国是乙肝大国，感染人数约7800万，且85%以上肝癌由慢性HBV感染引起，导致的肝癌相关死亡占所有癌症引起死亡病例的第二位，亟需开展基于乙肝治愈的相关基础和转化研究。
刘永振博士长期从事HBV相关研究，实验室利用分子生物学、病毒学、免疫学、化学生物学以及基因和蛋白组学等方法、结合体内动物模型研究乙肝病毒感染和致病机制。研究方向主要包括：1）HBV感染和复制基础病毒学的分子机制研究；2）HBV动物模型和抗病毒药物研发和评价；3）慢行HBV感染致病的病理学基础和乙肝功能性治愈的免疫学机制；
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1 Liu Y#, Liu H#, Hu Z#, Ding Y#, Pan XB, Zou J, Xi J, Yu G, Huang H, Luo MT, Guo F, Liu S, Sheng Q, Jia J, Zheng YT, Wang J, Chen X*, Guo JT*, Wei L*, Lu F*. HBV virions produced under nucleos(t)ide analogue treatment are mainly not infectious due to irreversible DNA chain termination. Hepatology. 2020 Feb; 71(2):463-476.
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2 Liu Y#, Zeng W, Xi J, Liu H, Liao H, Yu G, Chen X, Lu F*. Over-gap PCR amplification to identify presence of replication-competent HBV DNA from integrated HBV DNA: an updated occult HBV infection definition. Journal of Hepatology. 2019 Mar; 70(3):557.
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3 Liu Y#, Cafiero TR, Park D, Biswas A, Winer BY, Cho CH, Bram Y, Chandar V, O’ Connell AK, Gertje HP, Crossland N, Schwartz RE, Ploss A*. Targeted viral adaptation generates a simian-tropic hepatitis B virus that infects marmoset cells. Nature Communications. 2023 Jun; 14(1):3582.
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4 Liu Y#, Park D, Cafiero TR, Bram Y, Chandar V, Tseng A, Gertje HP, Crossland RA, Su L, Schwartz RE, Ploss A*. Molecular clones of genetically distinct hepatitis B virus genotypes reveal distinct host and drug treatment responses. JHEP Reports. 2022 Sep; 4(9):100535.
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5 Liu Y#, Maya S, Carver S, O’Connell A.K., Zen A, Gertje H.P., Crossland N., Ploss A*. Development of a dual channel detection system for pan-genotypic simultaneous quantification of hepatitis B and delta viruses. Emerging Microbes & Infections. 2024 April; (13): 2350167.
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6 Wang Y#, Liu Y#*, Zhang T#, Guan G, Mao T, Liu H, Zhang J, Lu F*, Chen X*. LncCDCA3L inhibits cell proliferation via a novel RNA structure-based crosstalk with CDCA3 in hepatocellular carcinoma. Liver International. 2022 Mar; 42(6):1432-1446. (Co-first author, Co-corresponding author)
