陈俏利实验室

Qian Ouyang^#, Qiaoli Chen^#, Shunyuan Ke, Longfei Ding, Xinyu Yang, Ping Rong, Weikuan Feng, Ye Cao, Qi Wang, Min Li, Shu Su, Wen Wei, Minjun Liu, Jin Liu, Xu Zhang, John Zhong Li, Hong-Yu Wang * and Shuai Chen*,Rab8a as a mitochondrial receptor for lipid droplets in skeletal muscle,Developmental Cell,2023,58(4):289-305

Wen Wei^#, Qiaoli Chen^#, Minjun Liu^#, Yang Sheng^#, Qian OuYang, Shu Su, Lei Fang, Antonio Vidal-Puig, Hong Yu Wang* and Shuai Chen*, TRIM24 is an insulin-responsive regulator of P-bodies, Nature Communications, 2022,13(1): p. 3972.

Kun Zhou^#, Qiaoli Chen^#, Jiamou Chen, Derong Liang, Weikuan Feng, Minjun Liu,Qi Wang, Ruizhen Wang, Qian Ouyang, Chao Quan* and Shuai Chen*, Spatiotemporal regulation of insulin signaling by liquid-liquid phase separation, Cell Discovery, 2022, 8(1): p. 64.

Xinyu Yang^#, Qiaoli Chen^#, Qian Ouyang, Ping Rong, Weikuan Feng, Chao Quan, Min Li, Qing Jiang, Hui Liang, Tong-Jin Zhao*, Hong Yu Wang* and Shuai Chen*, Tissue-specific splicing and dietary interaction of a mutant As160 allele determine muscle metabolic fitness in rodents, Diabetes, 2021,70(8):1826-1842

Qiaoli Chen^#, Ping Rong^#, Sangsang Zhu^#, Xinyu Yang, Qian OuYang Hong Yu Wang, Shuai Chen* Targeting RalGAPα1 in skeletal muscle to simultaneously improve postprandial glucose and lipid control,Science Advances 5, eaav4116, 2019

Qiaoli Chen^#, Ping Rong^#, Dijin Xu, Sangsang Zhu, Liang Chen, Bingxian Xie, Qian Du, Chao Quan, Yang Sheng, Tongjin Zhao, Peng Li, Hong Yu Wang*, Shuai Chen*, Rab8a deficiency in skeletal muscle causes hyperlipidemia and hepatosteatosis via impairment of muscle lipid uptake and storage. Diabetes, 2017, 66(9): 2387-2399

Qiaoli Chen^#, Bingxian Xie^#, Sangsang Zhu, Ping Rong, Yang Sheng, Serge Ducommun, Liang Chen, Chao Quan, Min Li, Kei Sakamoto, Carol MacKintosh, Shuai Chen* and Hong Yu Wang*, A TBC1D1^Ser231Ala knockin mutation partially impairs 5-aminoimidazole- 4-carboxamide-1-ß-D-ribofuranoside- but not exercise-induced muscle glucose uptake in mice. Diabetologia, 2017, 60(2): 336-345

Liang Chen^#, Qiaoli Chen^#, Bingxian Xie^#, Chao Quan, Yang Sheng, Sangsang Zhu, Ping Rong, Shuilian Zhou, Kei Sakamoto, Carol MacKintosh, Hong Yu Wang* and Shuai Chen*, Disruption of the AMPK–TBC1D1 nexus increases lipogenic gene expression and causes obesity in mice via promoting IGF1 secretion, PNAS, 2016, 113(26): 7219-24

Qiaoli Chen, Chao Quan, Bingxian Xie, Liang Chen, Shuilian Zhou, Rachel Toth, David G. Campbell, huangshuang Lu, Ryutaro Shirakawa, Hisanori Horiuchi, Chaojun Li, Zhongzhou Yang, Carol MacKintosh, Hong YuWang, Shuai Chen, GARNL1, a major RalGAP alpha subunit in skeletal muscle, regulates insulin-stimulated RalA activation and GLUT4 trafficking via interaction with 14-3-3 proteins. Cell Signal, 2014, 26: 1636-1648

Bingxian Xie, Qiaoli Chen, Liang Chen, Yang Sheng, Hong Yu Wang* and Shuai Chen*, The inactivation of RabGAP function of AS160 promotes lysosomal degradation of GLUT4 and causes postprandial hyperglycemia and hyperinsulinemia. Diabetes, 2016, 65(11):3327-3340

Liang Chen, Qiaoli Chen, Ping Rong. Hong Yu Wang* and Shuai Chen*, The energy sensing LKB−AMPKα1 pathway regulates IGF1 secretion and consequent activation of the IGF1R−PKB pathway in primary hepatocytes. FEBS J, 2017, 284(13): 2096-2109

Cong Xiang, Yannan Zhang, Qiaoli Chen, Aina Sun, Yamei Peng, Guoxin Zhang, Danxia Zhou, Yinyin Xie, Xiaoshuang Hou, Fangfang Zheng, Fan Wang, Zhenji Gan, Shuai Chen* and Geng Liu*; Increased glycolysis in skeletal muscle coordinates with adipose tissue in systemic metabolic homeostasis, Journal of Cellular and Molecular Medicine, 2021,25:7840-7854

Quan Chao^#, Li Min^#, Du Qian, Chen Qiaoli, Wang Hong, Campbell David G, Fang Lei, Xue Bin, MacKintosh Carol, Gao Xiang, Ouyang Kunfu, Wang Hong Yu, Chen Shuai*, SPEG Controls Calcium Re-Uptake into the Sarcoplasmic Reticulum Through Regulating SERCA2a by Its Second Kinase-Domain. Circulation Research, 2018, 2018(124): 712~726

Chao Quan^#, Qian Du^#, Min Li, Ruizhen Wang, Qian Ouyang, Shu Su, Sangsang Zhu, Qiaoli Chen, Yang Sheng, Liang Chen, Hong Wang, David G. Campbell, Carol MacKintosh, Zhongzhou Yang, Kunfu Ouyang, Hong Yu Wang & Shuai Chen, A PKB-SPEG signaling nexus links insulin resistance with diabetic cardiomyopathy by regulating calcium, Nature Communications, 2020;11(1):2186.

Sangsang Zhu^#, Chao Quan^#, Ruizhen Wang, Derong Liang, Shu Su, Ping Rong, Kun Zhou, Xinyu Yang, Qiaoli Chen, Min Li, Qian Du, Jingzi Zhang, Lei Fang, Hong Yu Wang* and Shuai Chen*, The RalGAPα1−RalA signal module protects cardiac function through regulating calcium homeostasis, Nature Communications, 2022, 13(1): p. 4278.

Xixi Tao^#, Ronglu Du^#, Shumin Guo^#, Xiangling Feng, Tingting Yu, Qian OuYang, Qiaoli Chen, Xutong Fan, Xueqi Wang, Chen Guo, Xiaozhou Li, Fengxia Xue, Shuai Chen, Minghan Tong, Michael Lazarus, Shengkai Zuo, Ying Yu*, Yujun Shen*, PGE2-EP3 axis controls brown adipose tissue development through 2 stabilization of WTAP protein, The EMBO Journal, 2022, 41(16): e110439

Chao Quan, Sangsang Zhu, Ruizhen Wang, Jiamou Chen, Qiaoli Chen, Min Li, Shu Su, Qian Du, Minjun Liu, Hong-Yu Wang*and Shuai Chen*, Impaired SERCA2a phosphorylation causes diabetic cardiomyopathy through impinging on cardiac contractility and precursor protein processing, Life Metabolism, 2022,1(1):54-66

Hong Yu Wang, Chao Quan, Chunxiu Hu, Bingxian Xie, Yinan Du, Liang Chen, Wei Yang, Qiaoli Chen, Bing Shen, Bian Hu, Zhihong Zheng, Haibo Zhu, Xingxu Huang, Guowang Xu and Shuai Chen, A lipidomics study reveals hepatic lipid signatures associating with deficiency of the LDL receptor in a rat model. Biology Open, 2016, 5(7): 979-986