陈帅实验室

Ouyang Q, Chen QL, Ke SY, Ding LF, Yang XY, Rong P, Feng WK, Cao Y, Wang Q, Li M, Su S, Wei W, Liu MJ, Liu J, Zhang X, Li JZ, Wang HY* and Chen S* (2023) Rab8a as a mitochondrial receptor for lipid droplets in skeletal muscle. Dev Cell 58, 289-305 

Quan C, Zhu SS, Wang RZ, Chen JM, Chen QL, Li M, Su S, Du Q, Liu MJ, Wang HY* and Chen S* (2022) Impaired SERCA2a phosphorylation causes diabetic cardiomyopathy through impinging on cardiac contractility and precursor protein processing. Life Metabolism DOI: 10.1093/lifemeta/loac013 (* corresponding authors)

Zhu SS, Quan C, Wang RZ, Liang DR, Su S, Rong P, Zhou K, Yang XY, Chen QL, Li M, Du Q, Zhang JZ, Fang L, Wang HY* and Chen S* (2022) The RalGAPα1−RalA signal module protects cardiac function through regulating calcium homeostasis. Nat Commun 13: 4278 DOI: 10.1038/s41467-022-31992-z (* corresponding authors)

Wei W, Chen QL, Liu MJ, Sheng Y, OuYang Q, Feng WK, Yang XY, Ding LF, Su S, Zhang JZ, Fang L, Vidal-Puig A, Wang HY* and Chen S* (2022) TRIM24 is an insulin-responsive regulator of P-bodies. Nat Commun 13: 3972 DOI: 10.1038/s41467-022-31735-0 (* corresponding authors)

Zhou K, Chen QL, Chen JM, Liang DR, Feng WK, Liu MJ, Wang Q, Wang RZ, OuYang Q, Quan C* and Chen S* (2022) Spatiotemporal regulation of insulin signaling by liquid-liquid phase separation. Cell Discov 8(1): 64 DOI: 10.1038/s41421-022-00430-1 (* corresponding authors)

Chen ZY, Sun YT, Wang ZM, Hong J, Xu M, Zhang FT, Zhou XQ, Rong P, Wang Q, Wang HY, Wang H*, Chen S* and Chen L* (2022) Rab2A regulates the progression of nonalcoholic fatty liver disease downstream of AMPK-TBC1D1 axis by stabilizing PPARg. Plos Biol 20(1): e3001522 DOI: 10.1371/journal.pbio.3001522 (* corresponding authors)

Tao XX, Du RL, Guo SM, Feng XL, Yu TT, OuYang Q, Chen QL, Fan XT, Wang XQ, Guo C, Li XZ, Xue FX, Chen S, Tong MH, Lazarus M, Zuo SK, Yu Y and Shen YJ (2022) PGE2-EP3 axis promotes brown adipose tissue formation through stabilization of WTAP RNA methyltransferase. EMBO J 41(16): e110439

Xiang C, Zhang YN, Chen QL, Sun AN, Peng YM, Zhang GX, Zhou DX, Xie YY, Hou XS, Zheng FF, Wang F, Gan Z, Chen S* and Liu G* (2021) Increased glycolysis in skeletal muscle coordinates with adipose tissue in systemic metabolic homeostasis. J Cell Mol Med 25: 7840-7854. (* corresponding authors)

Mak HY, OuYang Q, Tumanov S, Xu JS, Rong P, Dong FT, Lam SM, Wang XW, Lukmantara I, Du XM, Gao MM, Brown AJ, Gong X, Shui GH, Stocker R, Huang X, Chen S and Yang HY (2021) AGPAT2 interaction with CDP-diacylglycerol synthases promotes the flux of fatty acids through the CDP-diacylglycerol pathway. Nat Commun 12: 6877 DOI: 10.1038/s41467-021-27279-4

Rhein P, Desjardins EM, Rong P, Ahwazi D, Bonhoure N, Stolte J, Santos MD, Ovens A, Ehrlich AM, Sanchez Garcia JL, Ouyang Q, Kjølby MF, Membrez M, Jessen N, Oakhill JS, Treebak JJ, Maire P, Scott JW, Sanders M, Descombes P, Chen S, Steinberg GR and Sakamoto K (2021) Compound- and fiber type-selective requirement of AMPKg3 for insulin-independent glucose uptake in skeletal muscle. Mol Metab 51: 101228

Xiao LW, Liu J, Sun ZC, Yin YJ, Mao Y, Xu DQ, Liu L, Xu ZS, Guo QQ, Ding CY, Sun WP, Yang LK, Zhou Z, Zhou DX, Fu TT, Li JZ, Chen S, Xie XD and Gan ZJ (2021) AMPK-dependent and -independent coordination of mitochondrial function and muscle fiber type by FNIP1. PloS Genet 17(3): e1009488

Yang XY, Chen QL, OuYang Q, Rong P, Feng WK, Quan C, Li M, Jiang Q, Liang H, Zhao TJ, Wang HY* and Chen S*. (2021) Tissue-specific splicing and dietary interaction of a mutant As160 allele determine muscle metabolic fitness in rodents. Diabetes doi: 10.2337/db21-0039(* corresponding author)

Quan C, Du Q, Li M, Wang RZ, Su S, Zhu SS, Chen QL, Sheng Y, Chen L, Wang H, Campbell DG, MacKintosh C, Yang ZZ, Ouyang KF, Wang HY* and Chen S* (2020) A PKB-SPEG signaling nexus links insulin resistance with diabetic cardiomyopathy by regulating calcium homeostasis. Nat Commun 11(1): 2186 doi: 10.1038/s41467-020-16116-9 (* corresponding author)

Hao JW, Wang J, Guo HL, Zhao YY, Sun HH, Li YF, Lai XY, Zhao N, Wang X, Xie CC, Hong LX, Huang X, Wang HR, Li CB, Liang B, Chen S* and Zhao TJ* (2020) CD36 facilitates fatty acid uptake by dynamic palmitoylation-regulated endocytosis. Nat Commun 11(1): 4765 doi: 10.1038/s41467-020-18565-8 (* corresponding author)

Targeting RalGAPα1 in skeletal muscle to simultaneously improve postprandial glucose and lipid control. Science Advances DOI: 10.1126/sciadv.aav4116 (* corresponding author)

Quan C, Li M, Du Q, Chen QL, Wang H, Campbell D, Fang L, Xue B, MacKintosh C, Gao X, Ouyang KF, Wang HY and Chen S* (2018) SPEG controls calcium re-uptake into the sarcoplasmic reticulum through regulating SERCA2a by its second kinase-domain. Circ Res DOI: 10.1161/CIRCRESAHA.118.313916 (* corresponding author)