林兆宇实验室
林兆宇教授结合临床数据，利用细胞和疾病动物模型解析生理病理过程，揭示了免疫稳态失控导致的肥胖、脓毒症、炎症性肠病、矽肺等多种复杂炎症相关疾病的发病机制，发现了临床治疗多个潜在新靶标并探讨了新的防治策略，为临床治疗和新药研发提供了新的可能性。以第一或通讯作者在Immunity、Cell Death Differ、Embo J、PLoS Genet 、Cell Mol Immunol 、Ebiomedicine等主流学术期刊发表研究论文20余篇，获多项国家和省部级项目支持，主持国家自然科学基金面上项目与科技部重点研发计划课题。
学术兼职:
中国细胞生物学学会细胞死亡研究分会委员
中国生物物理学会肠道菌群分会委员
中国生物物理学会代谢生物学分会青年委员
中国江苏省动物学会理事
中国江苏省发育生物学学会代谢能量疗愈专业委员会委员
中国江苏省免疫学会衰老与免疫专业委员会委员
J Mol Cell Biol杂志青年编委
研究所邮箱：linzy@nicemice.cn
南大邮箱：linzy@nju.edu.cn
接受本校学生有关课程学习、学术研究、学业规划等方面的咨询，请提前通过邮件预约。时间：周二下午2点到4点；地点：模式所科研楼601b办公室。
本实验室主要研究方向为免疫对生理稳态的调控及其失调引起的炎症性疾病。由于免疫涉及几乎所有的核心生理稳态调控，所以其调控紊乱是脓毒症、炎症性肠病、矽肺、痛风和肿瘤等多种复杂疾病的重要原因。本课题组希望从分子机制角度解释这些复杂疾病的症状，并探寻疾病临床治疗靶点和方法。
具体研究方向如下：
(一) 固有免疫中细胞焦亡与相关疾病（脓毒症、矽肺、痛风等）的发病机制研究和治疗方法开发
(二) 机体代谢紊乱（肥胖）的调控机制研究与相应减肥疗法的开发
(三) 基于肠道菌群人源化小鼠模型研究炎症性肠病和结肠癌的发病机制和治疗方法
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1 Lin, Z*. and H.B. Ruan*, Cutting the Gordian knot: Untangling gasdermin C from pyroptosis. Immunity, 2025. 58(10): 2359-2361.
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2 Fan, C., X. Huang, J. Mei, X. Shi, H. Zhang, C. Liang, S. Cui, Y. Xing, B. Cao, W. Liu, H. Liu, B. Liu, W. Chang, M. Shao, G.H. Wei, Y.J. Liu, Z.J. Chen, Z. Lin*, T. Xu*, and Y. Jiu*, Macrophages form dendrite-like pseudopods to enhance bacterial ingestion. EMBO J, 2025. 44(17): 4772-4802.
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3 Zhang, Z., L. Li, Y. Ge, A. Chen, S. Diao, Y. Yang, Q. Chen, Y. Zhou, J. Shao, F. Meng, L. Yu, M. Tian, X. Qian, Z. Lin, C. Xie, B. Liu*, and R. Li*, Verteporfin-Mediated In Situ Nanovaccine Based on Local Conventional-Dose Hypofractionated Radiotherapy Enhances Antitumor and Immunomodulatory Effect. Adv Sci (Weinh), 2025. 12(20): e2413387.
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4 Pei, J., D. Zou, L. Li, L. Kang, M. Sun, X. Li, Q. Chen, D. Chen, B. Qu, X. Gao*, and Z. Lin*, Senp7 Deficiency Impairs Lipid Droplets Maturation in White Adipose Tissues via Plin4 DeSUMOylation. J Biol Chem, 2024.300(6):107319.
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5 Lin, Z*., Q. Chen, and H.B. Ruan*, To die or not to die: Gasdermins in intestinal health and disease. Semin Immunol, 2024. 71: 101865.
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6 Liu, Q., M. Li, M. Sun, R. Xin, Y. Wang, Q. Chen, X. Gao*, and Z. Lin*, Depletion of Gsdma1/2/3 alleviates PMA-induced epidermal hyperplasia by inhibiting the EGFR-Stat3/Akt pathway. J Mol Cell Biol, 2024. 16(1): mjad080.
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7 Li, X., T. Zhang, L. Kang, R. Xin, M. Sun, Q. Chen, J. Pei, Q. Chen, X. Gao*, and Z. Lin*, Apoptotic caspase-7 activation inhibits non-canonical pyroptosis by GSDMB cleavage. Cell Death Differ, 2023. 30(9): p. 2120-2134.
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8 Kang, L., J. Dai, Y. Wang, P. Shi, Y. Zou, J. Pei, Y. Tian, J. Zhang, V.C. Buranasudja, J. Chen, H. Cai, X. Gao, and Z. Lin, Blocking Caspase-1/Gsdmd and Caspase-3/-8/Gsdme pyroptotic pathways rescues silicosis in mice. PLoS Genet, 2022. 18(12): p. e1010515.
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9 Li, X., M. Sun, H. Qi, C. Ju, Z. Chen, X. Gao, and Z. Lin, Identification of a Chromosome 1 Substitution Line B6-Chr1BLD as a Novel Hyperlipidemia Model via Phenotyping Screening.Metabolites, 2022. 12(12):1276
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10 Wu, J., Q. Liu, X. Zhang, M. Tan, X. Li, P. Liu, L. Wu, F. Jiao, Z. Lin, X. Wu, X. Wang, Y. Zhao, and J.Ren, The interaction between STING and NCOA4 exacerbates lethal sepsis by orchestrating ferroptosis and inflammatory responses in macrophages. Cell Death Dis, 2022. 13(7): p. 653.
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11 Zou, Y., J. Pei, Y. Wang, Q. Chen, M. Sun, L. Kang, X. Zhang, L. Zhang, X. Gao, and Z. Lin, The Deficiency of SCARB2/LIMP-2 Impairs Metabolism via Disrupted mTORC1-Dependent Mitochondrial OXPHOS. Int J Mol Sci, 2022. 23(15):8634
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12 - Zhao, M., K. Ren, X. Xiong, Y. Xin, Y. Zou, J.C. Maynard, A. Kim, A.P. Battist, N. Koneripalli, Y. Wang, Q. Chen, R. Xin, C. Yang, R. Huang, J. Yu, Z. Huang, Z. Zhang, H. Wang, D. Wang, Y. Xiao, O.C. Salgado, N.N. Jarjour, K.A. Hogquist, X.S. Revelo, A.L. Burlingame, X. Gao, J. von Moltke, Z. Lin*, and H.B. Ruan*, Epithelial STAT6 O-GlcNAcylation drives a concerted anti-helminth alarmin response dependent on tuft cell hyperplasia and Gasdermin C. Immunity, 2022. 55(4): p. 623-638.e5.
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13 - Chen, Q., J. Zheng, D. Wang, Q. Liu, L. Kang, X. Gao*, and Z. Lin*, Nitrosonisoldipine is a selective inhibitor of inflammatory caspases and protects against pyroptosis and related septic shock. Eur J Immunol, 2021. 51(5): p. 1234-1245.
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14 - Zou, D., J. Pei, J. Lan, H. Sang, H. Chen, H. Yuan, D. Wu, Y. Zhang, Y. Wang, D. Wang, Y. Zou, D. Chen, J. Ren*, X. Gao*, and Z. Lin*, A SNP of bacterial blc disturbs gut lysophospholipid homeostasis and induces inflammation through epithelial barrier disruption. EBioMedicine, 2020. 52: p. 102652.
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15 - Zheng, J., D. Wang, Q. Chen, Q. Liu, Z. Lin, Q. Hu, X. Wu, X. Gao, Q. Li, and J. Ren, Hypertonic saccharide solution delays pyroptosis in murine macrophages regardless of the membrane binding of gasdermin D N-terminal. Eur J Immunol, 2020. 50(3): p. 464-467.
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16 - Wang, D., J. Zheng, Q. Hu, C. Zhao, Q. Chen, P. Shi, Q. Chen, Y. Zou, D. Zou, Q. Liu, J. Pei, X. Wu, X. Gao*, J. Ren*, and Z. Lin*, Magnesium protects against sepsis by blocking gasdermin D N-terminal-induced pyroptosis. Cell Death Differ, 2020. 27(2): p. 466-481.
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17 - Sun, M., S. Zheng, X. Gao*, and Z. Lin*, The role of immune cells in obesogenic memory. Cell Mol Immunol, 2020.
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18 - Zhang, X., Q. Xia, R. Wei, H. Song, J. Mi, Z. Lin, Y. Yang, Z. Sun, and K. Zou, Melatonin protects spermatogonia from the stress of chemotherapy and oxidation via eliminating reactive oxidative species. Free Radic Biol Med, 2019. 137: p. 74-86.
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19 - Wang, Y., P. Shi, Q. Chen, Z. Huang, D. Zou, J. Zhang, X. Gao*, and Z. Lin*, Mitochondrial ROS promote macrophage pyroptosis by inducing GSDMD oxidation. J Mol Cell Biol, 2019. 11(12): p. 1069-1082.
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20 - Chen, Q., P. Shi, Y. Wang, D. Zou, X. Wu, D. Wang, Q. Hu, Y. Zou, Z. Huang, J. Ren*, Z. Lin*, and X. Gao*, GSDMB promotes non-canonical pyroptosis by enhancing caspase-4 activity. J Mol Cell Biol, 2019. 11(6): p. 496-508.
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21 - Chen, Q., P. Shi, D. Wang, Q. Liu, X. Li, Y. Wang, D. Zou, Z. Huang, X. Gao*, and Z. Lin*, Epidermis-Activated Gasdermin-A3 Enhances Thermogenesis of Brown Adipose Tissue through IL-6/Stat3 Signaling. Am J Pathol, 2019. 189(5): p. 1041-1052.
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22 - Zou, J., B. Lai, M. Zheng, Q. Chen, S. Jiang, A. Song, Z. Huang, P. Shi, X. Tu, D. Wang, L. Lu, Z. Lin*, and X. Gao*, CD4+ T cells memorize obesity and promote weight regain. Cell Mol Immunol, 2018. 15(6): p. 630-639.
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23 - Luan, X.R., X.L. Chen, Y.X. Tang, J.Y. Zhang, X. Gao, H.P. Ke, Z.Y. Lin, and X.N. Zhang, CRISPR/Cas9-Mediated Treatment Ameliorates the Phenotype of the Epidermolytic Palmoplantar Keratoderma-like Mouse. Mol Ther Nucleic Acids, 2018. 12: p. 220-228.
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24 - Lin, Z.*, F. Liu, P. Shi, A. Song, Z. Huang, D. Zou, Q. Chen, J. Li, and X. Gao, Fatty acid oxidation promotes reprogramming by enhancing oxidative phosphorylation and inhibiting protein kinase C. Stem Cell Res Ther, 2018. 9(1): p. 47.
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25 - Lai, B., J. Zou, Z. Lin, Z. Qu, A. Song, Y. Xu, and X. Gao, Haploinsufficiency of hnRNP U Changes Activity Pattern and Metabolic Rhythms. Am J Pathol, 2018. 188(1): p. 173-183.
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26 - Song, A., S. Jiang, Q. Wang, J. Zou, Z. Lin, and X. Gao*, JMJD3 Is Crucial for the Female AVPV RIP-Cre Neuron-Controlled Kisspeptin-Estrogen Feedback Loop and Reproductive Function. Endocrinology, 2017. 158(6): p. 1798-1811.
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27 - Tang, A., P. Shi, A. Song, D. Zou, Y. Zhou, P. Gu, Z. Huang, Q. Wang, Z. Lin*, and X. Gao*, PP2A regulates kinetochore-microtubule attachment during meiosis I in oocyte. Cell Cycle, 2016. 15(11): p. 1450-61.
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28 - Lyu, Y.S., P.L. Shi, X.L. Chen, Y.X. Tang, Y.F. Wang, R.R. Liu, X.R. Luan, Y. Fang, R.H. Mei, Z.F. Du, H.P. Ke, E. Matro, L.E. Li, Z.Y. Lin, J. Zhao, X. Gao, and X.N. Zhang, A Small Indel Mutant Mouse Model of Epidermolytic Palmoplantar Keratoderma and Its Application to Mutant-specific shRNA Therapy. Mol Ther Nucleic Acids, 2016. 5: p. e299.
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29 - Jiang, S., Q. Wang, Z. Huang, A. Song, Y. Peng, S. Hou, S. Guo, W. Zhu, S. Yan, Z. Lin*, and X. Gao*, Gastric Bypass Surgery Reverses Diabetic Phenotypes in Bdnf-Deficient Mice. Am J Pathol, 2016. 186(8): p. 2117-2128.
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30 - Hou, S., L. Xian, P. Shi, C. Li, Z. Lin*, and X. Gao*, The Magea gene cluster regulates male germ cell apoptosis without affecting the fertility in mice. Sci Rep, 2016. 6: p. 26735.
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31 - Xian, L., S. Hou, Z. Huang, A. Tang, P. Shi, Q. Wang, A. Song, S. Jiang, Z. Lin, S. Guo, and X. Gao, Liver-specific deletion of Ppp2calpha enhances glucose metabolism and insulin sensitivity. Aging (Albany NY), 2015. 7(4): p. 223-32.
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32 - Shi, P., A. Tang, L. Xian, S. Hou, D. Zou, Y. Lv, Z. Huang, Q. Wang, A. Song, Z. Lin, and X. Gao, Loss of conserved Gsdma3 self-regulation causes autophagy and cell death. Biochem J, 2015. 468(2): p. 325-36.
| 基金种类 | 基金项目名称 |
|---|---|
| 国家科技重大专项2025ZD0550102 | T细胞介导的肥胖记忆调控能量代谢导致体重反弹的机制研究 |
| 国家自然科学基金32471238 | 锌抑制细胞焦亡防治脓毒症的机制研究 |
| 国家重点研发计划2018YFA0801101 | 标准化突变小鼠品系建立与质控 |
| 江苏省自然科学基金 BK20181260 | GSMDA/Gsdma3在表皮稳态维持中的作用机制研究 |
| 国家自然科学基金 31301217 | 脂肪酸代谢调节重编程的研究 |
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宋婧晗
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侯雅静
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赵茗淇
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张佳康
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耿志军
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王炼
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查多多
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李璐
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张小凤
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张天逊
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陈丹宁
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李鳗芸
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冯子安
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辛茹月
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武迪
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高琴
