林兆宇实验室
PI简介：
林兆宇博士，2006-2012年在南京大学模式动物研究所攻读博士学位，师从高翔教授，并在美国圣路易斯华盛顿大学进行3年访问学者研究。回国后2012-2013年在南京大学化学化工学院进行博士后研究；2014年加入模式动物研究所任副研究员；2019年受聘为南京大学副教授，医药生物技术国家重点实验室研究员。
联系方式：
办公室：025-58641511
研究所邮箱：linzy@nicemice.cn
南大邮箱：linzy@nju.edu.cn
研究所邮箱：linzy@nicemice.cn
南大邮箱：linzy@nju.edu.cn
本实验室主要研究方向为免疫对生理稳态的调控及其失调引起的炎症性疾病。由于免疫涉及几乎所有的核心生理稳态调控，所以其调控紊乱是脓毒症、炎症性肠病、矽肺、痛风和肿瘤等多种复杂疾病的重要原因。本课题组希望从分子机制角度解释这些复杂疾病的症状，并探寻疾病临床治疗靶点和方法。
具体研究方向如下：
(一) 固有免疫中细胞焦亡与相关疾病（脓毒症、矽肺、痛风等）的发病机制研究和治疗方法开发
(二) 机体代谢紊乱（肥胖）的调控机制研究与相应减肥疗法的开发
(三) 基于肠道菌群人源化小鼠模型研究炎症性肠病和结肠癌的发病机制和治疗方法
代表性论文（#第一作者； *通讯作者）
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1 Kang, L., J. Dai, Y. Wang, P. Shi, Y. Zou, J. Pei, Y. Tian, J. Zhang, V.C. Buranasudja, J. Chen, H. Cai, X. Gao, and Z. Lin, Blocking Caspase-1/Gsdmd and Caspase-3/-8/Gsdme pyroptotic pathways rescues silicosis in mice. PLoS Genet, 2022. 18(12): p. e1010515.
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2 Li, X., M. Sun, H. Qi, C. Ju, Z. Chen, X. Gao, and Z. Lin, Identification of a Chromosome 1 Substitution Line B6-Chr1BLD as a Novel Hyperlipidemia Model via Phenotyping Screening.Metabolites, 2022. 12(12):1276
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3 Wu, J., Q. Liu, X. Zhang, M. Tan, X. Li, P. Liu, L. Wu, F. Jiao, Z. Lin, X. Wu, X. Wang, Y. Zhao, and J.Ren, The interaction between STING and NCOA4 exacerbates lethal sepsis by orchestrating ferroptosis and inflammatory responses in macrophages. Cell Death Dis, 2022. 13(7): p. 653.
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4 Zou, Y., J. Pei, Y. Wang, Q. Chen, M. Sun, L. Kang, X. Zhang, L. Zhang, X. Gao, and Z. Lin, The Deficiency of SCARB2/LIMP-2 Impairs Metabolism via Disrupted mTORC1-Dependent Mitochondrial OXPHOS. Int J Mol Sci, 2022. 23(15):8634
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5 - Zhao, M., K. Ren, X. Xiong, Y. Xin, Y. Zou, J.C. Maynard, A. Kim, A.P. Battist, N. Koneripalli, Y. Wang, Q. Chen, R. Xin, C. Yang, R. Huang, J. Yu, Z. Huang, Z. Zhang, H. Wang, D. Wang, Y. Xiao, O.C. Salgado, N.N. Jarjour, K.A. Hogquist, X.S. Revelo, A.L. Burlingame, X. Gao, J. von Moltke, Z. Lin*, and H.B. Ruan*, Epithelial STAT6 O-GlcNAcylation drives a concerted anti-helminth alarmin response dependent on tuft cell hyperplasia and Gasdermin C. Immunity, 2022. 55(4): p. 623-638.e5.
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6 - Chen, Q., J. Zheng, D. Wang, Q. Liu, L. Kang, X. Gao*, and Z. Lin*, Nitrosonisoldipine is a selective inhibitor of inflammatory caspases and protects against pyroptosis and related septic shock. Eur J Immunol, 2021. 51(5): p. 1234-1245.
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7 - Zou, D., J. Pei, J. Lan, H. Sang, H. Chen, H. Yuan, D. Wu, Y. Zhang, Y. Wang, D. Wang, Y. Zou, D. Chen, J. Ren*, X. Gao*, and Z. Lin*, A SNP of bacterial blc disturbs gut lysophospholipid homeostasis and induces inflammation through epithelial barrier disruption. EBioMedicine, 2020. 52: p. 102652.
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8 - Zheng, J., D. Wang, Q. Chen, Q. Liu, Z. Lin, Q. Hu, X. Wu, X. Gao, Q. Li, and J. Ren, Hypertonic saccharide solution delays pyroptosis in murine macrophages regardless of the membrane binding of gasdermin D N-terminal. Eur J Immunol, 2020. 50(3): p. 464-467.
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9 - Wang, D., J. Zheng, Q. Hu, C. Zhao, Q. Chen, P. Shi, Q. Chen, Y. Zou, D. Zou, Q. Liu, J. Pei, X. Wu, X. Gao*, J. Ren*, and Z. Lin*, Magnesium protects against sepsis by blocking gasdermin D N-terminal-induced pyroptosis. Cell Death Differ, 2020. 27(2): p. 466-481.
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10 - Sun, M., S. Zheng, X. Gao*, and Z. Lin*, The role of immune cells in obesogenic memory. Cell Mol Immunol, 2020.
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11 - Zhang, X., Q. Xia, R. Wei, H. Song, J. Mi, Z. Lin, Y. Yang, Z. Sun, and K. Zou, Melatonin protects spermatogonia from the stress of chemotherapy and oxidation via eliminating reactive oxidative species. Free Radic Biol Med, 2019. 137: p. 74-86.
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12 - Wang, Y., P. Shi, Q. Chen, Z. Huang, D. Zou, J. Zhang, X. Gao*, and Z. Lin*, Mitochondrial ROS promote macrophage pyroptosis by inducing GSDMD oxidation. J Mol Cell Biol, 2019. 11(12): p. 1069-1082.
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13 - Chen, Q., P. Shi, Y. Wang, D. Zou, X. Wu, D. Wang, Q. Hu, Y. Zou, Z. Huang, J. Ren*, Z. Lin*, and X. Gao*, GSDMB promotes non-canonical pyroptosis by enhancing caspase-4 activity. J Mol Cell Biol, 2019. 11(6): p. 496-508.
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14 - Chen, Q., P. Shi, D. Wang, Q. Liu, X. Li, Y. Wang, D. Zou, Z. Huang, X. Gao*, and Z. Lin*, Epidermis-Activated Gasdermin-A3 Enhances Thermogenesis of Brown Adipose Tissue through IL-6/Stat3 Signaling. Am J Pathol, 2019. 189(5): p. 1041-1052.
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15 - Zou, J., B. Lai, M. Zheng, Q. Chen, S. Jiang, A. Song, Z. Huang, P. Shi, X. Tu, D. Wang, L. Lu, Z. Lin*, and X. Gao*, CD4+ T cells memorize obesity and promote weight regain. Cell Mol Immunol, 2018. 15(6): p. 630-639.
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16 - Luan, X.R., X.L. Chen, Y.X. Tang, J.Y. Zhang, X. Gao, H.P. Ke, Z.Y. Lin, and X.N. Zhang, CRISPR/Cas9-Mediated Treatment Ameliorates the Phenotype of the Epidermolytic Palmoplantar Keratoderma-like Mouse. Mol Ther Nucleic Acids, 2018. 12: p. 220-228.
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17 - Lin, Z.*, F. Liu, P. Shi, A. Song, Z. Huang, D. Zou, Q. Chen, J. Li, and X. Gao, Fatty acid oxidation promotes reprogramming by enhancing oxidative phosphorylation and inhibiting protein kinase C. Stem Cell Res Ther, 2018. 9(1): p. 47.
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18 - Lai, B., J. Zou, Z. Lin, Z. Qu, A. Song, Y. Xu, and X. Gao, Haploinsufficiency of hnRNP U Changes Activity Pattern and Metabolic Rhythms. Am J Pathol, 2018. 188(1): p. 173-183.
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19 - Song, A., S. Jiang, Q. Wang, J. Zou, Z. Lin, and X. Gao*, JMJD3 Is Crucial for the Female AVPV RIP-Cre Neuron-Controlled Kisspeptin-Estrogen Feedback Loop and Reproductive Function. Endocrinology, 2017. 158(6): p. 1798-1811.
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20 - Tang, A., P. Shi, A. Song, D. Zou, Y. Zhou, P. Gu, Z. Huang, Q. Wang, Z. Lin*, and X. Gao*, PP2A regulates kinetochore-microtubule attachment during meiosis I in oocyte. Cell Cycle, 2016. 15(11): p. 1450-61.
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21 - Lyu, Y.S., P.L. Shi, X.L. Chen, Y.X. Tang, Y.F. Wang, R.R. Liu, X.R. Luan, Y. Fang, R.H. Mei, Z.F. Du, H.P. Ke, E. Matro, L.E. Li, Z.Y. Lin, J. Zhao, X. Gao, and X.N. Zhang, A Small Indel Mutant Mouse Model of Epidermolytic Palmoplantar Keratoderma and Its Application to Mutant-specific shRNA Therapy. Mol Ther Nucleic Acids, 2016. 5: p. e299.
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22 - Jiang, S., Q. Wang, Z. Huang, A. Song, Y. Peng, S. Hou, S. Guo, W. Zhu, S. Yan, Z. Lin*, and X. Gao*, Gastric Bypass Surgery Reverses Diabetic Phenotypes in Bdnf-Deficient Mice. Am J Pathol, 2016. 186(8): p. 2117-2128.
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23 - Hou, S., L. Xian, P. Shi, C. Li, Z. Lin*, and X. Gao*, The Magea gene cluster regulates male germ cell apoptosis without affecting the fertility in mice. Sci Rep, 2016. 6: p. 26735.
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24 - Xian, L., S. Hou, Z. Huang, A. Tang, P. Shi, Q. Wang, A. Song, S. Jiang, Z. Lin, S. Guo, and X. Gao, Liver-specific deletion of Ppp2calpha enhances glucose metabolism and insulin sensitivity. Aging (Albany NY), 2015. 7(4): p. 223-32.
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25 - Shi, P., A. Tang, L. Xian, S. Hou, D. Zou, Y. Lv, Z. Huang, Q. Wang, A. Song, Z. Lin, and X. Gao, Loss of conserved Gsdma3 self-regulation causes autophagy and cell death. Biochem J, 2015. 468(2): p. 325-36.
| 基金种类 | 基金项目名称 |
|---|---|
| 国家科技部重点研发计划 2018YFA0801100 | 发育编程及其代谢调节 |
| 江苏省自然科学基金 BK20181260 | GSMDA/Gsdma3在表皮稳态维持中的作用机制研究 |
| 国家自然科学基金 31301217 | 脂肪酸代谢调节重编程的研究 |
硕士研究生
科研助理
硕士毕业生
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武迪 wudi@nicemice.cn
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高琴 gaoq@nicemice.cn
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张天逊 zhangtx@nicemice.cn
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陈丹宁 chendn@nicemice.cn
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李鳗芸 limy@nicemice.cn
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冯子安 fengza@nicemice.cn
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辛茹月
