万国强实验室

Cen, S.#, Hou, Z.#, Zhang, Y.#, Wang, N., Zhao, Z., Li, A.*, Wan, G.*, Zhang, T.*, Gao, X.* (2026). Obacunone mitigates cisplatin-induced ototoxicity by activating CRHBP-mediated autophagy. Biochemical Pharmacology, 247:117759.

Zhao, Z.#, Li, A.#, Zhu, Y., Cen, S., Liu, Q., Zhang, Y., Fan, H., Hou, Z., Ma, D.-B., Liu, D., Duan, M.*, Qian, X.*, Chai, R.*, Wan, G.*, Gao, X.* (2025). Blood-Labyrinth Barrier Damage Mediated by Granzyme from Cytotoxic Lymphocytes Results in Hearing Loss in Systemic Lupus Erythematosus. Proceedings of the National Academy of Sciences of the United States of America, 122(33):e2423240122.

Gong, S.#, Liu, Q.#, Du, H.#, Zhang, L., Zhu, C., Xu, Z., Gao, X.*, Zhu, G.J.*, Wan, G.* (2025). The phospholipid scramblase PLSCR5 is regulated by POU4F3 and required for hair cell stereocilia homeostasis and auditory functions. Journal of Genetics and Genomics, 52(10):1211-1223.

Chen, Y.#, Cheng, C.#, Li, A.#, Ma, D., Li, S., Wang, H., Gao, S., Liu, D., Song, P., Yu, C.*, Qian, X.*, Wan, G.*, Gao, X.* (2025). Pinoresinol Diglucoside Attenuates Nuclear Receptor Coactivator 4-Mediated Ferritinophagy Associated with Cisplatin-Induced Hearing Loss, Advanced Science, e2408777.

Huang, Y.#, Chen, Z.#, Chen, J.#, Liu, J.#, Qiu, C., Liu, Q., Zhang, L., Zhu, G.J., Ma, X.* , Sun, S.* , Shi, Y.S.* , Wan, G.* (2025). Direct reprogramming of fibroblasts into spiral ganglion neurons by defined transcription factors. Cell Proliferation, e13775. 

Qiu, C.#, Zhang, L.#, Yong, C., Hu, R., Sun, Y., Wang, B., Fang, L., Zhu, G.J., Lu, Q., Wang, J.*, Ma, X.*, Zhang, L.*, Wan, G.* (2024). Stub1 promotes degradation of the activated Diaph3: A negative feedback regulatory mechanism of the actin nucleator. Journal of Biological Chemistry, 300(10):107813. 

Huang, Y., Zhang, L., Sun, Y., Liu, Q., Chen, J., Qian, X., Gao, X.*, Zhu, G.J.*, Wan, G.* (2024). A human-specific cytotoxic neopeptide generated by the deafness gene Cingulin. Journal of Genetics and Genomics, 51(11):1215-1227. 

Liu, Q.#, Zhang, L.#, Chen, Z., He, Y., Huang, Y., Qiu, C., Zhu, C., Zhou, D., Gan, Z.*, Gao, X.*, Wan, G.* (2024). Metabolic Profiling of Cochlear Organoids Identifies α-Ketoglutarate and NAD+ as Limiting Factors for Hair Cell Reprogramming. Advanced Science, e2308032. 

Ye, C., Zhang, T.Z., Zang, Y.Y., Shi, Y.S.*, and Wan, G.* (2024). TMEM63B regulates postnatal development of cochlear sensory epithelia via thyroid hormone signaling. Journal of Genetics and Genomics, 51(6):673-676.  

Zhu, G.J.#, Huang, Y.#, Zhang, L.#, Yan, K.#, Qiu, C., He, Y., Liu, Q., Zhu, C., Morín, M., Moreno-Pelayo, M.Á., Zhu, M.S., Cao, X., Zhou, H., Qian, X., Xu, Z.*, Chen, J.*, Gao, X.*, Wan, G.* (2023). Cingulin regulates hair cell cuticular plate morphology and is required for hearing in human and mouse. EMBO Molecular Medicine, e17611. 

Liu, Q., Zhang, L., Zhu, M.S., and Wan, G. (2021). High-throughput screening on cochlear organoids identifies VEGFR-MEK-TGFB1 signaling promoting hair cell reprogramming. Stem Cell Reports, 16:2257-2273.

Chen, Z., Huang, Y., Yu, C., Liu, Q., Qiu, C., and Wan, G. (2021). Cochlear Sox2+ glial cells are potent progenitors for spiral ganglion neuron reprogramming induced by small molecules. Frontiers in Cell and Developmental Biology, 9:728352.

Yu, C., Gao, H.M., and Wan, G. (2021). Macrophages Are Dispensable for Postnatal Pruning of the Cochlear Ribbon Synapses. Frontiers in Cellular Neuroscience, 15:736120.

Zhu, G.J.#, Gong, S.#, Ma, D.B.#, Tao, T.#, He, W.Q.#, Zhang, L., Wang, F., Qian, X.Y., Zhou, H., Fan, C., Wang, P., Chen, X., Zhao, W., Sun, J., Chen, H., Wang, Y., Gao, X., Zuo, J., Zhu, M.S.*, Gao, X.*, Wan, G.* (2020). Aldh inhibitor restores auditory function in a mouse model of human deafness. PLOS Genetics, 16(9):e1009040.

Du, H.#, Ye, C.#, Wu, D.#, Zang, Y.Y., Zhang, L., Chen, C., He, X.Y., Yang, J.J., Hu, P., Xu, Z., Wan, G.*and Shi, Y.S.* (2020). The cation channel TMEM63B is an osmosensor required for hearing. Cell Reports, 31(5):107596