石云实验室
实验室:025-58641548
研究所邮箱:shiyun@nicemice.cn
南大邮箱:yunshi@nju.edu.cn
研究方向:
1. 中枢神经系统突触生理和可塑性。
2. 谷氨酸受体/辅助亚基的生理功能以及在病理过程中的作用。
3. 谷氨酸受体的上膜转运和突触定位的机制。
4. 机械门控离子通道的结构和功能。
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1 He, L., Sun, J., Gao, Y., Li, B., Wang, Y., Dong, Y., An, W., Li, H., Yang, B., Ge, Y., Zhang, X. C., Shi, Y. S., & Zhao, Y. (2021). Kainate receptor modulation by NETO2. Nature, 599(7884), 325–329.
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2 Li, Q. Q., Chen, J., Hu, P., Jia, M., Sun, J. H., Feng, H. Y., Qiao, F. C., Zang, Y. Y., Shi, Y. Y., Chen, G., Sheng, N., Xu, Y., Yang, J. J*., Xu, Z*., Shi, Y. S*. (2022). KKK879-881 motif is an ER-retention signal in GluN2A-NMDA receptor. Molecular psychiatry, 27(8), 3115.
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3 Peng, S. X., Pei, J., Rinaldi, B., Chen, J., Ge, Y. H., Jia, M., Wang, J., Delahaye-Duriez, A., Sun, J. H., Zang, Y. Y., Shi, Y. Y., Zhang, N., Gao, X., Milani, D., Xu, X., Sheng, N., Gerard, B., Zhang, C., Bayat, A., Liu, N*., Yang, J. J*., Shi, Y. S*. (2022). Dysfunction of AMPA receptor GluA3 is associated with aggressive behavior in human. Molecular psychiatry, 27(10), 4092–4102.
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4 Li, Q. Q., Chen, J., Hu, P., Jia, M., Sun, J. H., Feng, H. Y., Qiao, F. C., Zang, Y. Y., Shi, Y. Y., Chen, G., Sheng, N., Xu, Y., Yang, J. J*., Xu, Z*., Shi, Y. S*. (2022). Enhancing GluN2A-type NMDA receptors impairs long-term synaptic plasticity and learning and memory. Molecular psychiatry, 27(8), 3468–3478.
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5 Teng, X. Y., Hu, P., Chen, Y., Zang, Y., Ye, X., Ou, J., Chen, G*., Shi, Y. S*. (2022). A novel Lgi1 mutation causes white matter abnormalities and impairs motor coordination in mice. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 36(3), e22212.
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6 Duan, G. F., Tang, X. H., Jia, M., Wu, D., Shi, Y. S*. (2023). Kainate receptors GluK1 and GluK2 differentially regulate synapse morphology. Synapse (New York, N.Y.), 77(1), e22255.
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7 Sun, J. H., Chen, J., Ayala Valenzuela, F. E., Brown, C., Masser-Frye, D., Jones, M., Romero, L. P., Rinaldi, B., Li, W. L., Li, Q. Q., Wu, D., Gerard, B., Thorpe, E*., Bayat, A*., & Shi, Y. S*. (2021). X-linked neonatal-onset epileptic encephalopathy associated with a gain-of-function variant p.R660T in GRIA3. PLoS genetics, 17(6), e1009608.
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8 Peng, S. X., Wang, Y. Y., Zhang, M., Zang, Y. Y., Wu, D., Pei, J., Li, Y., Dai, J., Guo, X., Luo, X., Zhang, N., Yang, J. J., Zhang, C., Gao, X., Liu, N*., & Shi, Y. S*. (2021). SNP rs10420324 in the AMPA receptor auxiliary subunit TARP γ-8 regulates the susceptibility to antisocial personality disorder. Scientific reports, 11(1), 11997.
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9 Jiang, C. H., Wei, M., Zhang, C*., & Shi, Y. S*. (2021). The amino-terminal domain of GluA1 mediates LTP maintenance via interaction with neuroplastin-65. Proceedings of the National Academy of Sciences of the United States of America, 118(9), e2019194118.
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10 Wu, D., Zang, Y. Y., Shi, Y. Y., Ye, C., Cai, W. M., Tang, X. H., Zhao, L., Liu, Y., Gan, Z., Chen, G. Q., Xu, Y., Yang, J. J*., Shi, Y. S*. (2020). Distant coupling between RNA editing and alternative splicing of the osmosensitive cation channel Tmem63b. The Journal of biological chemistry, 295(52), 18199–18212.
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11 Du, H., Ye, C., Wu, D., Zang, Y. Y., Zhang, L., Chen, C., He, X. Y., Yang, J. J., Hu, P., Xu, Z., Wan, G*., Shi, Y. S*. (2020). The Cation Channel TMEM63B Is an Osmosensor Required for Hearing. Cell reports, 31(5), 107596.
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12 Li, Y. J., Duan, G. F., Sun, J. H., Wu, D., Ye, C., Zang, Y. Y., Chen, G. Q., Shi, Y. Y., Wang, J., Zhang, W*., Shi, Y. S*. (2019). Neto proteins regulate gating of the kainate-type glutamate receptor GluK2 through two binding sites. The Journal of biological chemistry, 294(47), 17889–17902.
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13 Duan, G. F., Ye, Y., Xu, S., Tao, W., Zhao, S., Jin, T., Nicoll, R. A., Shi, Y. S*., Sheng, N*. (2018). Signal peptide represses GluK1 surface and synaptic trafficking through binding to amino-terminal domain. Nature communications, 9(1), 4879.
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14 Chen, J., Du, Y., He, X., Huang, X*., Shi, Y. S*. (2017). A Convenient Cas9-based Conditional Knockout Strategy for Simultaneously Targeting Multiple Genes in Mouse. Scientific reports, 7(1), 517.
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15 Niu, Y., Dai, Z., Liu, W., Zhang, C., Yang, Y., Guo, Z., Li, X., Xu, C., Huang, X., Wang, Y., Shi, Y. S*., Liu, J. J*. (2017). Ablation of SNX6 leads to defects in synaptic function of CA1 pyramidal neurons and spatial memory. eLife, 6, e20991.
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16 He, X. Y., Li, Y. J., Kalyanaraman, C., Qiu, L. L., Chen, C., Xiao, Q., Liu, W. X., Zhang, W., Yang, J. J., Chen, G., Jacobson, M. P., Shi, Y. S*. (2016). GluA1 signal peptide determines the spatial assembly of heteromeric AMPA receptors. Proceedings of the National Academy of Sciences of the United States of America, 113(38), E5645–E5654.
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17 - Granger AJ, Shi Y, Lu W, Cerpas M, Nicoll RA. (2013) LTP requires an extrasynaptic pool of glutamate receptors independent of subunit type. Nature. 493(7433),495-500
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18 Herring, B. E#., Shi, Y#., Suh, Y. H., Zheng, C. Y., Blankenship, S. M., Roche, K. W., & Nicoll, R. A. (2013). Cornichon proteins determine the subunit composition of synaptic AMPA receptors. Neuron, 77(6), 1083–1096.
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19 Gray, J. A., Shi, Y., Usui, H., During, M. J., Sakimura, K., & Nicoll, R. A. (2011). Distinct modes of AMPA receptor suppression at developing synapses by GluN2A and GluN2B: single-cell NMDA receptor subunit deletion in vivo. Neuron, 71(6), 1085–1101.
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20 Shi, Y#., Suh, Y. H#., Milstein, A. D., Isozaki, K., Schmid, S. M., Roche, K. W., & Nicoll, R. A. (2010). Functional comparison of the effects of TARPs and cornichons on AMPA receptor trafficking and gating. Proceedings of the National Academy of Sciences of the United States of America, 107(37), 16315–16319.
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21 Shi, Y., Lu, W., Milstein, A. D., & Nicoll, R. A. (2009). The stoichiometry of AMPA receptors and TARPs varies by neuronal cell type. Neuron, 62(5), 633–640.
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22 Lu, W., Shi, Y., Jackson, A. C., Bjorgan, K., During, M. J., Sprengel, R., Seeburg, P. H., & Nicoll, R. A. (2009). Subunit composition of synaptic AMPA receptors revealed by a single-cell genetic approach. Neuron, 62(2), 254–268.
基金种类 | 基金项目名称 |
---|---|
中央高校基本科研业务费专项资金,0903-14380029 | 新型离子通道的功能研究 |
江苏省重点研发计划(社会发展)项目-临床前沿技术,BE2019707 | 重大脑疾病动物模型快速建立和转化应用的研究 |
国家自然基金委员会,重大计划培育项目,91849112 | 谷氨酸受体调节亚基TARPg-8缺失导致精神分裂症样脑衰老的机制研究 |
科技部重大专项 2019YFA0801603 | 大脑组织中神经与血管偶联发育及血脑屏障建立和稳态维持的调控机制 |
国家自然基金委员会,面上项目,32170951 | Neuroplastin调控兴奋/抑制性突触传递和可塑性的机制研究 |
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